What is the antidote for vitamin K?

Fresh frozen plasma (FFP) has been the mainstay for urgent anticoagulation reversal in patients taking vitamin K antagonists (eg, warfarin). FFP requires blood group typing and thawing before use.

What is the antidote for overdose of warfarin?

Vitamin K (phytonadione)

How is warfarin toxicity treated?

FFP is effective at lowering the INR and was historically first-line therapy for warfarin toxicity with serious or life-threatening bleeding, although it has now been superceded by PCC, which lowers the INR more rapidly. If PCC or rFVIIa are not available, 4 units of FFP may be administered instead.

How is anticoagulant overdose treated?

Specific treatment

1. If the PT is elevated, give phytonadione (vitamin K1), 10–25 mg orally, and increase the dose as needed to restore the PT to normal.
2. Do not treat prophylactically—wait for the evidence of anticoagulation (elevated PT)

What is antidote for Phytonadione?

INR >10 with no significant bleeding: Hold warfarin for several doses and give 2.5 to 5 mg of vitamin K1. If INR is not sufficiently reduced in 24 hrs, use additional vitamin K1 as necessary.

What is the heparin antidote?

Expert opinion: Despite of the low therapeutic index, protamine is the only registered antidote of heparins. The toxicology of protamine depends on a complex interaction of the high molecular weight, a cationic peptide with the surfaces of the vasculature and blood cells.

What is the antidote for heparin and warfarin?

Individuals anticoagulated with warfarin or heparin are typically treated with specific antidotes such as vitamin K or protamine, respectively, if they bleed or require surgery.

Which Drug is the correct reversal agent for warfarin?

Reversal agents are used to counter the effects of anticoagulants in life-threatening situations of uncontrolled bleeding. Vitamin K is the reversal agent for warfarin, and FDA recently approved the first reversal agent for the class of “new anticoagulant drugs,” Praxbind (idrucizumab).

What is the antidote to digoxin?

In the case of severe digoxin intoxication, an antidote digoxin immune Fab (Digibind) is available. Digibind binds and inactivates digoxin.

What is the antidote for paracetamol?

Intravenous acetylcysteine is the antidote to treat paracetamol overdose and is virtually 100% effective in preventing liver damage when given within 8 hours of the overdose.

Why vitamin K is used as an antidote in active bleeding due to warfarin?

Warfarin. Warfarin is an oral vitamin K antagonist (VKA) that works by blocking the regeneration of vitamin K epoxide, thus inhibiting the syntheses of vitamin K-dependent clotting factors, which include factors II, VII, IX, and X as well as the anticoagulant proteins C and S.

What is the antidote for heparin in case of toxicity overdose?