What is exemestane?

Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It irreversibly binds to the active site causing permanent inhibition necessitating de novo synthesis to restore enzymatic function.

What is exemestane (FCE 24304)?

di Salle E, Ornati G, Giudici D, Lassus M, Evans TR, Coombes RC: Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J Steroid Biochem Mol Biol. 1992 Sep;43 (1-3):137-43.

How can the metabolism of exemestane be increased or decreased?

The metabolism of Exemestane can be increased when combined with Carbamazepine. The serum concentration of Exemestane can be decreased when it is combined with Cenobamate. The metabolism of Exemestane can be decreased when combined with Ciprofloxacin. The metabolism of Exemestane can be decreased when combined with Clarithromycin.

What is adrenal fatigue (AF)?

PMID: 27557747 PMCID: PMC4997656 DOI: 10.1186/s12902-016-0128-4 Abstract Background: The term “adrenal fatigue” (“AF”) has been used by some doctors, healthcare providers, and the general media to describe an alleged condition caused by chronic exposure to stressful situations.