What is KDM1A gene?

KDM1A (Lysine Demethylase 1A) is a Protein Coding gene. Diseases associated with KDM1A include Cleft Palate, Psychomotor Retardation, And Distinctive Facial Features and Kbg Syndrome.

Where is KDM6A located?

Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene….UTX (gene)

What is an LSD1 inhibitor?

LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival.

What is lysine demethylase?

Lysine demethylases are a group of proteins that are categorized into two functional enzymatic families. The first family includes LSD1 and LSD. LSD1 is a flavin-dependent monoamine oxidase and the LSD2 is the only homologue of LSD1 in the human genome [77].

Is KDM6A a tumor suppressor?

A demethylating protein called KDM6A is a known tumor suppressor, and its function is often lost in bladder cancer as a result of inactivating mutations. There is no way to directly target the loss of the tumor suppressor, but Ler et al. found another strategy to effectively treat tumors with this mutation.

What does the KDM6A gene do?

The KDM6A gene provides instructions for making an enzyme called lysine-specific demethylase 6A that is found in many organs and tissues of the body. Lysine-specific demethylase 6A functions as a histone demethylase. Histone demethylases are enzymes that modify proteins called histones.

What is acetylation used for?

Proteins that replicate DNA and repair damaged genetic material are created directly by acetylation. Acetylation also helps in DNA transcription. Acetylation determines the energy that proteins use during duplication and this determines the accuracy of copying the genes.

What does KDM1A mean?

KDM1A (Lysine Demethylase 1A) is a Protein Coding gene. Diseases associated with KDM1A include Cleft Palate, Psychomotor Retardation, And Distinctive Facial Featuresand Kbg Syndrome.

What are the Biosystems pathways for KDM1A?

4 BioSystems pathways for KDM1A Gene Androgen receptor signaling pathway Coregulation of Androgen receptor activity Notch signaling pathway Notch-mediated HES/HEY network 11 Reactome pathways for KDM1A Gene Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Chromatin modifying enzymes

How many drugs are there for KDM1A gene?

(19) Drugs for KDM1A Gene – From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek Name Status Disease Links Group Role Mechanism of Action Clinical Trials Tranylcypromine Approved, Investigational MalaCards Medline Plus Pharma inhibitor 28 FAD Approved MalaCards Medline Plus Pharma 0 Vafidemstat Investigational MalaCards Medline Plus Pharma

What are the miRNAs for KDM1A gene?

LSD1 CRISPR/Cas9 KO Plasmid (h2) miRNA for KDM1A Gene miRTarBase miRNAs that target KDM1A hsa-miR-137(MIRT004579)