What are examples of multimodal analgesia?

Multimodal analgesia regimens are both patient- and procedure-specific and utilize varying combinations of local and/or regional analgesic techniques and non-opioid analgesics (eg, acetaminophen, nonsteroidal anti-inflammatory drugs [NSAIDs], cyclooxygenase [COX]-2–specific inhibitors) and analgesic adjuncts (eg.

Is gabapentin considered an analgesic?

Background: Gabapentin is an anticonvulsant drug that has analgesic properties for acute postoperative pain.

What are multimodal analgesics?

Multimodal analgesia or “balanced analgesia” combines analgesics from two or more drug classes or analgesic techniques that employ different mechanisms of action, targeting different (peripheral or central) pain pathways, thus achieving a synergistic effect at lower analgesic doses. 1, 2.

Why is multimodal analgesia used?

Overall, a multimodal analgesic approach should be used when treating postoperative pain, as it can potentially reduce side effects and provide the benefit of treating pain through different cellular pathways.

When are side effects from an Nsaid most likely to occur?

Hepatotoxicity secondary to NSAIDs can occur at any time, but is most likely to happen six to 12 weeks after administration. Risk factors for NSAID-induced idiosyncratic hepatotoxicity include female sex, age greater than 50 years, and underlying autoimmune disease.

Is gabapentin an Nsaid?

Examples would include gabapentin, tramadol and amitriptyline. NSAIDs can cause stomach and intestinal problems, damage the kidneys and less commonly the liver and bone marrow. These problems are uncommon to rare, especially with appropriate monitoring.

What is multimodal therapy for acute pain?

Multimodal analgesia involves the concurrent use of primarily non-opioid analgesics to take advantage of the additive, if not synergistic, effects that produce superior analgesia while decreasing opioid use and opioid-related side effects 9.

When are side effects from an NSAID most likely to occur?