What is the best treatment for B-cell lymphoma?

Diffuse large B-cell lymphoma Most often, the treatment is chemotherapy (chemo), usually with a regimen of 4 drugs known as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), plus the monoclonal antibody rituximab (Rituxan). This regimen, known as R-CHOP, is most often given in cycles 3 weeks apart.

What is B-cell clonality?

Clonality analysis of B-cell populations can aid in the diagnosis of lymphoproliferative disorders. This test is used to support or refute the diagnosis of B-cell lymphomas/leukemias.

What is B-cell lymphoproliferative disorder and treatment?

B-cell lymphoproliferative disorders are conditions in the blood involving uncontrolled growth of lymphocytes (white blood cells). These conditions include such cancers as multiple myeloma, Hodgkin lymphoma and chronic lymphocytic leukemia (CLL), and such precursor conditions as monoclonal B-cell lymphocytosis.

Can B-cell lymphoma curable?

Some types of B-cell lymphomas can be cured. Treatment can slow progression in others. If there’s no sign of cancer after your primary treatment, it means you’re in remission. You’ll still need to follow up for several years to monitor for recurrence.

How do you calculate clonality?

Currently, a number of different approaches can be used to detect clonality, including Southern blotting analyses, polymerase chain reaction (PCR) assays, and most recently, high-throughput sequencing [or next-generation sequencing (NGS)]; see Table 1.

How do you measure clonality?

For assessing B-cell clonality, multiplex PCR reactions are performed for the detection of IGH and kappa light chain (IGK) gene rearrangements, followed by fragment analysis using GeneScan or heteroduplex analysis.

Is lymphoma B-cell curable?

How fast does B-cell lymphoma spread?

Symptoms can start or get worse in just a few weeks. The most common symptom is one or more painless swellings. These swellings can grow very quickly.

How is malignancy/clonality determined in B-cell lymphoma?

The method used for determining malignancy or clonality in B-cell lymphomas is by immunohistochemical staining for light chains to show that the sample has lymphocytes expressing all kappa or lambda light chains. It is called light chain restriction and shows the presence of lymphocytic clone. [1] [2]

What are the treatment options for diffuse large B-cell lymphoma?

This lymphoma, which starts in the space between the lungs (the mediastinum), is treated like early stage diffuse large B-cell lymphoma. A common treatment is 6 courses of CHOP chemo plus rituximab (R-CHOP). This may be followed by radiation to the mediastinum.

How is primary mediastinal B-cell lymphoma treated?

Primary mediastinal B-cell lymphoma This lymphoma, which starts in the space between the lungs (the mediastinum), is treated like early stage diffuse large B-cell lymphoma. A common treatment is 6 courses of CHOP chemo plus rituximab (R-CHOP). This may be followed by radiation to the mediastinum.

What are the different types of B-cell non-Hodgkin lymphoma?

Treating B-Cell Non-Hodgkin Lymphoma 1 Diffuse large B-cell lymphoma. Diffuse large B-cell lymphoma (DLBCL) tends to grow quickly. 2 Primary mediastinal B-cell lymphoma. This lymphoma, which starts in the space between the lungs… 3 Follicular lymphoma. This type of lymphoma often grows slowly and responds well to treatment,…