What does CTCF stand for?

-binding factor
CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator protein, blocking the communication between enhancers and promoters.

What is Convergent orientation?

There are three relative orientations that two genes can assume: (1) convergent orientation, where transcription of both genes proceeds in opposite directions and toward each other, (2) divergent orientation, where transcription of both genes proceeds in opposite directions, away from each other and toward genetic …

What is the CTCF binding site?

CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures like the nuclear lamina. It also defines the boundaries between active and heterochromatic DNA.

What are convergent gene pairs?

Convergent gene pairs can produce transcripts with complementary sequences. We had shown that mRNA duplexes form in vivo in Saccharomyces cerevisiae via interactions of mRNA overlapping 3′-ends and can lead to posttranscriptional regulatory events.

What is divergent transcription?

Summary. Divergent transcription, defined as two polymerases transcribing on opposite directions from the same promoter, is occurring at most promoters in organisms as diverse as yeast and mammals.

Can a repressor bind to an enhancer?

Transcriptional repressors can bind to promoter or enhancer regions and block transcription. Like the transcriptional activators, repressors respond to external stimuli to prevent the binding of activating transcription factors.

Do CTCF binding patterns correlate with transcription at thousands of mouse genes?

Promoter-proximal CTCF binding correlates with transcription at thousands of mouse genes. a,Frequency of genomic regions and their density of CTCF motifs bound by CTCF in at least one adult mouse tissue. The genomic regions were classified into promoters, enhancers (identified in ESCs and NPCs), gene bodies, and random regions.

Jianrong Lu, in Epigenetic Gene Expression and Regulation, 2015 CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic contexts.

What is CCTC binding factor?

CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic contexts. CTCF was first isolated and cloned on the basis of its ability to bind to highly divergent 50–60 bp sequences within the promoter region of the chicken Myc gene [153].

What is CTCF and how does it interact with other proteins?

CTCF has been also found to interact with transcription factors such as YY1, which is a zinc finger protein capable of activating or repressing transcription depending on the promoter context. Like CTCF, YY1 also binds to DNA in a methylation-sensitive manner.