What type of drug is alfaxalone?

Alfaxalone, also known as alphaxolone or alphaxalone and used under the trade name Alfaxan®, is a neuroactive steroid and general anesthetic drug used in dogs and cats. It can be used as an induction agent or for general anesthesia.

Can humans use Alfaxan?

Currently, a human form of alfaxalone is in development under the name “Phaxan”: alfaxalone will be dissolved in 7-sulfo-butyl-ether-β-cyclodextrin, which, unlike the cyclodextrin used in Alfaxan, is not toxic to people.

Who makes alfaxalone?

Jurox
In 2000, Jurox incorporated alfaxalone into a cyclodextrin carrier creating Alfaxan. Users began to enjoy the safety and effectiveness of the drug without the side effects.

Is alfaxalone a steroid?

Alfaxalone is a neuroactive steroid molecule, with central effects. Despite being an analogue of progesterone, alfaxalone does not bind to sex hormone, glucocorticoid, or mineralocorticoid receptors69.

How long does Alfaxan last?

SUMMARY. Alfaxalone has been used to induce general anesthesia for many years, but only recently has a new formulation with preservatives become available in the United States. This formulation has a shelf life of 28 days after first use.

Why is alfaxalone controlled?

One commenter noted that controlling alfaxalone as a schedule IV controlled substance is appropriate because it could be abused in a manner similar to other schedule IV CNS depressants.

Is Alfaxan a barbiturate?

6.15. Alphaxalone (Figure 2) is a steroid anesthetic, a neurosteroid, used for short-term anesthesia that is similar in its effects to barbiturates but has a wider margin of safety than barbiturates and produces less apnea on induction.

Is Alfaxan a controlled substance?

Alfaxalone is classified by the Drug Enforcement Agency as a Schedule IV controlled substance.

Is Alfaxan a controlled drug?

How long does Alfaxan take to work?

THE EFFECT IS DOSE DEPENDENT Both alfaxalone doses provided sedation but the recovery time with alfaxalone 2mg/kg was shorter (82 +/- 24 minutes) than for the 5mg/kg dose (127 +/- 33 minutes).

Is alfaxalone a controlled substance?

As such, the DEA is scheduling alfaxalone as a controlled substance under the CSA. (3) Abuse of 5[alpha]-pregnan-3[alpha]-ol-11,20-dione (alfaxalone) may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule III.

Can you reverse alfaxalone?

There is no reversal agent for alfaxalone; however, other drugs administered that cause cardiorespiratory depression should be antagonised if possible.

What is alfaxalone used for?

From Wikipedia, the free encyclopedia Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan, is a neuroactive steroid and general anesthetic which is used currently in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic.

Is alfaxalone the same as allopregnanolone?

Alfaxalone is also a derivative of allopregnanolone, differing from it only by the addition of the C11 ketone. Other closely related steroids include ganaxolone, hydroxydione, minaxolone, pregnanolone, and renanolone.

Is alphaxolone a steroid?

(verify) Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan, is a neuroactive steroid and general anesthetic which is used in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic.

When was alfaxalone released in the US?

Alfaxan was released in the UK in 2007, central Europe in 2008, Canada in 2011, and the United States in 2012. Currently, a human form of alfaxalone is in development under the name “Phaxan”: alfaxalone will be dissolved in 7-sulfo-butyl-ether-β-cyclodextrin, which, unlike the cyclodextrin used in Alfaxan, is not toxic to people.