What does KET do for liver?

What does KET do for liver?

Long term ketamine use can cause inflammation and irritation to the urinary bladder and urethra, and similar changes have recently been described in the biliary tract, resulting in an acute or chronic cholestatic liver injury that can resemble sclerosing cholangitis.

Why is etomidate not available in Australia?

CHOICE AND DOSES OF AGENTS etomidate is not available in Australia, and may be best avoided due to ongoing concerns: it causes adrenal suppression which may be linked to increased mortality in septic patients (though many argue that etomidate is safe)

What drug reverses rocuronium?

Sugammadex is a selective relaxant binding agent indicated for the reversal of moderate to deep NMB,3 with a high affinity for rocuronium. Sugammadex encapsulates neuromuscular blocking agents (e.g., rocuronium), inactivating them, resulting in the reversal of the NMB.

Does ketamine fail the ketamine-tolerant patient?

The ketamine-tolerant patient presents a quandary to clinicians who aren’t familiar with this phenomenon. The first time I encountered this, I was baffled and aborted the procedure after giving 200 mg ketamine. Eventually I realized that the drug isn’t “failing” to work, but rather we are failing to administer a sufficiently high dose.

Does ketamine affect the contractility of failing human myocardium?

The direct effects of ketamine on the failing human myocardium are unknown. This study examined the effects of ketamine on contractility of human failing and nonfailing myocardium in vitro.

What are the hemodynamic effects of ketamine?

This creates a ceiling effect on the neurologic action of ketamine. There may be some concern about hemodynamic effects of very large doses, because ketamine can cause catecholamine release (increasing the Bp) and also has some negative inotropic properties (potentially dropping the Bp).

Is ketamine harmful to the human body?

Liver and urinary toxicity are common among regular users of high doses of ketamine for recreational purposes. Ketamine is an NMDA receptor antagonist , and that accounts for most of its actions except the antidepressive effect, the mechanism of which is a matter of much research and debate.

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